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If you have any concerns or questions about how semaglutide may affect your hunger, its best to discuss them with your healthcare provider

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What the Clinical Trial Evidence Shows Phase 2 trials published in NEJM (2023) reported dose-dependent mean resting heart rate increases of approximately 57 bpm at higher doses

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Nutrients 16 (12), 1859

Orexigenic ghrelin stimulates AgRP/NPY neurons to inhibit satiety neurons and promote appetite, whereas anorexigenic leptin stimulates POMC neurons to activate satiety neurons and inhibit appetite