Mixing: Reconstitute gently by running media down the vial wall
TL;DR: The GLP-1 receptor agonist landscape in 2026 spans four distinct compounds: semaglutide (selective GLP-1 RA, MW 4113.58 Da, injectable and oral), tirzepatide (dual GLP-1/GIP agonist, MW 4813.45 Da), retatrutide (triple GLP-1/GIP/glucagon agonist, MW ~4500 Da, Phase 3), and orforglipron (non-peptide oral GLP-1 agonist, MW 541.65 Da, FDA-approved April 2026)
When you can see your progress charted over weeks, the temporary discomfort of side effects feels more manageable because you can see the trend improving
The guide to tirzepatide injection in the thigh covers the specific positioning and needle angle for that alternative site
Some GLP-1 medications specifically injectable varieties also require refrigeration, much like insulin
Trying to reuse the same single-use pen can similarly increase the risk of infection