In 3 of the studies, patients were treated with liraglutide, whereas exenatide was used in the other 2 studies
P = 0.05), with a possible increased risk of kidney cancer (HR 1.38
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GLP-1 and NMDA receptors are expressed throughout the mammalian brain and, although reports indicate that GLP-1 analogues engage central appetite circuits through distinct subpopulations of neurons (most notably in the brainstem and the hypothalamus) 36 , feedforward neural pathways modulated by inhibition of NMDA receptors specifically in GLP-1-receptor-positive neurons may differ from those engaged by exclusive activation of GLP-1 receptors
Regulate blood sugar levels
The biological mechanism suggests it could occur, but the degree of appetite change and its long-term metabolic impact have not been defined in controlled clinical trials