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These medications work through several mechanisms: Slowing gastric emptying : Food stays in your stomach longer, creating extended feelings of fullness Reducing appetite : They act on brain centers that control hunger signals Improving insulin sensitivity : They help your body use insulin more effectively Suppressing glucagon : They prevent your liver from releasing stored glucose into the bloodstream Currently available GLP-1 medications include: Also Read: 11 Essential Facts About Semaglutide The Hidden Long-Term Effects of GLP-1 Medications While the dramatic weight loss and improved blood sugar levels make headlines, several concerning long-term effects deserve more attention: 1
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Everything in life seems to have both pros and cons, and GLP-1s are no different
The most commonly reported side effects were gastrointestinal, such as nausea, vomiting, diarrhoea, or constipation
The lifestyle modification requirement delays treatment
In the clinical experience of some authors of this Advisory, another approach is to maintain individuals at the lowest effective dose and escalate only as needed (i.e., when weight reduction ceases or efficacy wanes), although shortages of medications at lower doses may be a barrier
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