However, there are on the horizon no cardiorenal outcome studies comparing SGLT-2 inhibitors with GLP-1RA, so it is likely that we must rely on indirect comparisons
In a January 2024 Drug Safety Communication, the FDA stated that their preliminary evaluation does not find that these medicines cause suicidal thoughts or actions
Men with pre-existing low testosterone may find that their levels improve modestly with weight loss but remain below the threshold needed for healthy libido
At 12 months, semaglutide reaches 13 to 16% while tirzepatide reaches 18 to 23%
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Both compounds significantly reduce liver fat, but retatrutide has stronger data