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The key differences that make this fragment scientifically interesting are: Absence of IGF-1 stimulation: Unlike full-length GH, this compound does not appear to stimulate hepatic IGF-1 production in laboratory models, an important distinction for researchers wishing to study metabolic GH-related pathways without the confounding variable of IGF-1 pathway activation

Although pain mechanisms are different in neuropathic or nociceptive pain, vitamin B12 as a pain killer has had positive effects in these studies, similar to our studied FM patients [11, 12]

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19 Workup can include radiographs, ultrasonography, or magnetic resonance imaging (MRI)