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Oral semaglutide, for example, needs to be taken in the morning, on an empty stomach, with a small amount of water, and you typically have to wait at least 30 minutes before eating, drinking anything else, or taking other medication

No cortisol spikes

Roughly 46% of Retatrutide 12 mg patients reached at least 25% weight loss at 48 weeks - a threshold that sits squarely inside the clinical outcome range historically associated with sleeve gastrectomy and Roux-en-Y gastric bypass

10.1016/s0006-8993(99)01408-0 46 YangK.KumamotoE.FurueH.LiY

doi: 10.1159/000324757

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