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For example, a study discovered that a reduced kcal diet completed with an increase in protein is a practical addition to a reduction in body weight, fat mass, and cholesterol levels, compared to that of another diet without protein but with a supplement of simple sugars [116]

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"There are currently not enough high-quality studies with large sample sizes that reflect the broader population." Things to consider include: Side effects: Berberine may have gastrointestinal side effects including nausea, pain, bloating and diarrhea

The Cochrane Collaborations tool for assessing risk of bias in randomised trials

Lipotropic compounds are designed as medical alternatives to add years to your life by effective and healthy reduction in fats