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It is crucial to acknowledge the limitations within the current evidence supporting this approach

PRISMA reporting guidelines were used to select 56 articles with a total of 126 patients with hydroquinone-associated ochronosis

It has been reported that patients with UC show increased levels of DNA oxide, enhanced ROS production in neutrophils, and decreased antioxidant mechanisms 14

GHK-Cu has the strongest mechanistic literature of the four

It is a powerful natural antioxidant tonic property, strengthens the walls of our blood vessels, and helps to slow down the processes of skin aging, increases collagen and elastin synthesis

Basal serum concentrations of the endocannabinoid ligands N-arachidonylethanolamide and 2-arachidonoylglycerol were significantly reduced in women with major depression relative to matched controls, indicating a deficit in peripheral endocannabinoid activity (Hill et al., 2009)