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Individual pharmacology and genetics: Variability in GLP-1 receptor signaling and metabolic response means some people are simply stronger or weaker responders

While its topical safety record is strong, its systemic safety and efficacy for treating medical conditions have not been established through comprehensive, large-scale, independent Phase 3 human trials

doi: 10.1124/dmd.115.063826 100 GriffithsJAMazmanianSK

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Prevalence of residual B cell function and its metabolic consequences in type 1 (insulin-dependent) diabetes

It also causes sunburn, which can lead to peeling, sensitivity, and long-term pigmentation