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10.1007/s00213-020-05634-5 168 ZimmermanA

mansoni TGR at low OPZ concentrations, a rough estimation of k i , the resulting half-time value ( t 1/2 ), and K I , were 0.04 min 1 , 17.3 min, and 32.8 M in the GR assay, and 0.06 min 1 , 11.5 min, 140 M in the TrxR assay, respectively

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While brain interstitial fluid tau concentrations are reported to be nearly twice as high during the active period of the rest-activity cycle in humans [8], it is noteworthy that, to the best of our knowledge, no study has investigated whether the deletion of core clock genes, simulating circadian disruption, leads to an increase in tau hyperphosphorylation

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