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All assays relevant to cAMP, LDH, PKA, ATP and Seahorse XFe24 extracellular flux measurements are detailed

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Knocking down ACTL6A had no impact on NRF2 expression (Supplementary Fig 6h)

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Elevated lactate concentrations within the tumor microenvironment can activate GPR81 receptors located on the cytoplasmic membrane of cells, subsequently facilitating MCT1-mediated lactate uptake (57,58)