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In MM patients, 24% of tumors exhibit copy number loss of CDKN2A ( CDK4 , CCND1 , and MDM2 are amplified in 28%, 18%, and 19% of samples respectively, and TP53 mutations occur in 9.0% of MMs ( CDKN2A loss than MM, MM tends to show a greater frequency of CCND1 and CDK4 amplification (120, 122), implying CDK4 blocking agents may achieve a desired anti-tumor effect on MM

Hold brief case conferences for complicated cases, such as bariatric surgery, high-risk cardiac patients, or those with renal impairment, to establish personalized plans

We recommend focusing on consistent water intake throughout the day

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The next step for a drug or medical device is to test for efficacy or to test if it works

Wang et al., 2024)