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41589_2021_915_MOESM17_ESM.mpeg Supplementary Video 15 Representative movie for 100 ns MD simulation of oxidized GPX4 U46C-K48L (C46-SOOO-) with the camera zoomed in for a close-up of the active site

Enhanced purine/pyrimidine metabolites support RNA/protein synthesis and transcriptional reprogramming, which is promoted also by some fasting-related metabolites, possibly via epigenetic modulations

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This suggests possible crosstalk between GGTDelta1, GGTDelta7 and ChaC1 via the ER stress/CHOP pathway

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MolModa: accessible and secure molecular docking in a web browser