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Fasting metformin concentrations were measured after the washout period at baseline (day 1, visit 2) and after the 3 month study (day 1, visit 5) ~12 h after the last study dose (ESM Table 1)

Adhesion molecule expression in human synovial tissue

A notable RCT is the pioglitazone in early PD trial, which failed to demonstrate the possibility of pioglitazone delaying disease progression in early-stage PD patients [38]

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Continue gentle swirling for 23 minutes