Suzuki K, Okada H, Takemura G, Takada C, Tomita H, Yano H, Muraki I, Zaikokuji R, Kuroda A, Fukuda H, Nishio A, Takashima S, Suzuki A, Miyazaki N, Fukuta T, Yamada N, Watanabe T, Doi T, Yoshida T, Kumada K, Ushikoshi H, Yoshida S, Ogura S
Key Phase 2 Findings In a randomized study of 65 patients with obesity or overweight with comorbidities, patients received ASC30 monthly for three months
The topline SURPASSCVOT results were first released in a corporate communication, and this subsequent peerreviewed New England Journal of Medicine publication from December 2025 provided the full randomized, doubleblind, eventdriven dataset, including detailed cardiovascular, renal, and safety outcomes monitored for a median of 4 years
Jennifer, a 52-year-old attorney, was losing cognitive endurance during long, complex cases
Activated JNK phosphorylates and inhibits the activity of the anti-apoptotic protein Bcl-2, while simultaneously promoting the oligomerization of the pro-apoptotic protein Bax on the mitochondrial membrane
Currently, weight loss surgery stands out as the most effective approach to address obesity