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Lancet Diabetes Endocrinol 2(10):801809

Any dose adjustment should be made gradually and accompanied by enhanced lifestyle interventions and frequent follow-up

2017 No serious adverse effects at therapeutic doses up to 1000 g/kg for 90 days

[56] Cellular aging and autophagy [edit] Pathological aging and metabolic diseases are often characterized by defective mitochondria, the accumulation of misfolded proteins, and cellular senescence

Higher alcohol consumption is also linked to a higher risk of macular degeneration (Coleman 2010)