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doi: 10.1016/j.rasd.2018.09.003

Because immune benefits are systemic rather than visible, results are often felt before they are measured

[1] Chronic excessive vitamin A intake can cause hepatotoxicity, bone abnormalities, and teratogenic effects

This is achieved through advanced formulations that allow for better absorption, making serums more efficient in addressing skin concerns compared to moisturizers alone

In this comprehensive and evidence-driven review, the objective is to scrutinize the repercussions, diagnosis, and management of these often overlooked yet prevalent and challenging-to-treat symptoms encountered in cirrhosis (Figure 1)

Access this article Similar content being viewed by others Abbreviations ACSL4: Acyl-CoA synthetase long-chain family member 4 AEC2s: Alveolar epithelial Type2 cells AIFM2: Apoptosis-inducing factor mitochondrial 2 ALL: Acute lymphoblastic leukemia ANXA7: Annexin A7 AR: Androgen receptor BH4: Tetrahydrobiopterin BMP: BODIPY-modified polyamide CHMP5: Charged multivesicular body protein 5 CHMP6: Charged multivesicular body protein 6 CoQ10: Ubiquinone-10 CoQ10H2: Ubiquinol CRPC: Castration-resistant prostate cancer CTRP: Cancer Therapeutics Response Portal CTD: C-terminal domain CYP2J2: Cytochrome P450 2J2 DAMP: Damage-associated molecular patterns DHFR: Dihydrofolate reductase DHODH: Dihydroorotate dehydrogenase EMT: Epithelial-mesenchymal transformation ER: Estrogen receptor ESCC: Esophageal squamous cell carcinoma ETC: Electronic transport chain FSEN1: Ferroptosis sensitizer Ferroptosis sensitizer 1 FSP1: Ferroptosis suppressor protein 1 GCH1: GTP cyclohydrolase-1 GPX4: Glutathione peroxidase 4 GSH: Glutathione HA: Hyaluronic acid HCC: Hepatocellular carcinoma HMGB1: High mobility group box 1 ICD: Immunogenic cell death IPP: Isopentenyl pyrophosphate IR: Ionizing radiation LPCAT3: Lysophosphatidylcholine acyltransferase 3 LSCs: Lung cancer stem cells MDA: Malondialdehyde MOF: Metal-organic framework MK4: Menaquinone-4 PDAC: Pancreatic ductal adenocarcinoma PDCD6IP: Programmed cell death 6-interacting protein PIE: Propofol injectable emulsion PLOOH: Phospholipid hydroperoxide PUFA: Polyunsaturated fatty acid PUFA-CoA: Coenzyme A-activated polyunsaturated fatty acid PUFA-PLs: Polyunsaturated fatty acids phospholipids Py-RSL: Pyridine RAS-selective lethal ligand QLD: QiLing Decoction RCD: Regulated cell death ROS: Reactive oxygen species RT: Radiotherapy RTA: RTA Radical-trapping antioxidant TME: Tumor microenvironment TSS: Transcriptional start site TSG101: Tumor susceptibility 101 VKH2: Vitamin K hydroquinone VK: Vitamin K VKORC1L1: Vitamin K epoxide reductase complex subunit 1 like 1 4HNE : 4-Hydroxynonenal References Galluzzi L et al (2018) Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018