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Exclusive use of folic acid in treating vitamin B12-deficient megaloblastic anemia could result in progressive and irreversible neurologic damage

In contrast, GSNO(ox) inhibited proteasome activity, but was not reversed by ascorbate

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As shown in Figures 6A,B, ATT-I treatment significantly decreased DAI score and attenuated body weight loss compared with the DSS group, whereas co-treatment with Erastin effectively reversed these beneficial effects

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These reactions are often blamed on detox, but they may indicate that folate treatment does not match the patients underlying methylation pattern