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For instance, new research presented at ACC.25 in March 2025 indicated that tirzepatide improved kidney function and cardiovascular outcomes in patients with obesity and heart failure with preserved ejection ejection (HFpEF) compared with placebo at one year, showing a 38% lower rate of cardiovascular death or worsening heart failure

The electronic search encompassed a number of databases, including PubMed, MEDLINE, Embase, Web of Science, and Reprotox, covering the period from database inception through January 2026

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At the low end, 54% of Willow reviews are low-star (1 and 2 star) with an average rating of 2.9, and OrderlyMeds had 30% low-star reviews and an average rating of 3.7