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More recent data from non-diabetic obese populations (the STEP trials) showed similar cardiovascular safety profiles, with no increase in serious cardiac adverse events
Greater BMI reductions were observed among females and among patients who reached higher semaglutide doses (1.7 mg), whereas type 2 diabetes was associated with a lower percentage BMI reduction
Potential Risks and Who Needs Extra Caution Immune Reactions Peptides, aggregates, impurities, or contaminants may trigger antibodies, allergy, loss of effect, or reactions that are difficult to predict
Cost containment was similarly dramatic, with the diagnosis code group seeing a 15% increase in PMPM costs compared to 79% in the control group
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Glucagon receptor activation in retatrutide may increase resting heart rate, requiring careful cardiovascular monitoring [1]
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