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The primary symptoms of PCOS include: Irregular or absent menstrual cycles Excessive hair growth (hirsutism) on the face, chin, or body Acne and oily skin Weight gain or difficulty losing weight PCOS can disrupt the body's ability to regulate insulin, leading to weight fluctuations and metabolic challenges

The controversy remains whether the impaired paracellular barrier plays a role in the transepithelial passage of gliadin

JAMA 298:11801188 Lago RM, Singh PP, Nesto RW (2007) Congestive heart failure and cardiovascular death in patients with prediabetes and type 2 diabetes given thiazolidinediones: a meta-analysis of randomised clinical trials

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Liraglutide has demonstrated a reduction in the risk of knee surgery, cartilage loss velocity, and the need for intra-articular steroid injections in patients with obesity and knee osteoarthritis

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