tirzepatide liraglutide Comparison of Clinical Efficacy and Safety of Tirzepatide, and Semaglutide in Patients with Obesity and Without T2D: A Semaglutide vs Liraglutide vs Tirzepatide

Hughes EC, et al

Energy production and fatigue management Fatigue is a frequent complaint during tirzepatide therapy

Wang, J., Zhou, X., Pan, B., Wang, H., Shi, F., Gan, W., Yang, L., Yin, X., Xu, B

Nearly all compounds showed an excellent selectivity profiles against DASH- (dipeptidyl peptidase-IV activity and/or structure homologues)-enzymes (DPP2, DPP8, DPP9) and non-DASH-enzymes (post-proline cleaving enzyme (PPCE), neutral endopeptidase (NEP), aminopeptidase P (APP) and aminopeptidase N (APN)

Individual variation is substantialsome patients experience no nausea while others require anti-emetic medications or dose reduction

Conditional gene targeting in mouse pancreatic ss-Cells: analysis of ectopic Cre transgene expression in the brain