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The only molecules that can passively diffuse across the BBB are gases such as oxygen and carbon dioxide, and small lipid-soluble molecules with a molecular weight under 400 Da or containing less than 8 hydrogen bonds (e.g., ethanol, antidepressants) [17]

Currently, there are limited randomized controlled and double-blind clinical trials of traditional Chinese medicine for ulcerative colitis, while QCHS has been proven to have a clear effect on clinical remission and mucosal healing in patients with moderately active UC [22, 23]

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10.5409/wjcp.v10.i5.84 198

These health restrictions exist because Glutathione metabolism occurs primarily in the liver and kidneys, making dysfunction in these organs particularly dangerous for IV administration

A co-lyophilised blend reduces handling steps and the number of reconstitution events, which is convenient when a research protocol consistently uses the two peptides at a 1:1 mass ratio