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Importantly, numerous studies have revealed CYP2D6 as the rate-limiting enzyme responsible for converting the pharmacologically inactive tamoxifen to its metabolites endoxifen (4-OH-N-desmethyl-tamoxifen) and 4-hydroxytamoxifen
Yang R, Zhou S, Huang J, Kang D, Chen Y, Wang X, et al
[DOI] [PubMed] [Google Scholar] 128.Aoyama K., Watabe M., Nakaki T
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