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Marty Makary, nominated to head the FDA under Trump, will be arriving to the position apparently aligned with the compounders

Routine monitoring of serum calcitonin or using thyroid ultrasound is of uncertain value for early detection of MTC in patients treated with Ozempic Important Safety Information for RYBELSUS WARNING: RISK OF THYROID C-CELL TUMORS In rodents, semaglutide causes dose-dependent and treatment-duration-dependent thyroid C-cell tumors at clinically relevant exposures

A 2023 meta-analysis of 11 randomized controlled trials found that GLP-1 monotherapy achieved average body weight reductions of 1222%, with improvements in blood glucose control, blood pressure, and cholesterol profiles as secondary benefits

In rarer cases, IGF blood levels might be lower because of a poor diet which can be corrected with adequate nutritional intake

Reality check: Responses to L-Carnitine vary

Any thermogenic effect from side effects such as nausea is described as incidental, not the mechanism