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In the acute administration paradigm, animals received a single intraperitoneal infusion (over 30 minutes) of cisplatin at doses ranging from 9 mg/kg to 15 mg/kg, and were monitored for up to 7 days

Minatohara et al., 2016)

(Lausanne) 13 , 863184 (2022)

By administering the peptide during a fasted state when insulin is low, you maximize the peptides ability to stimulate fat breakdown without metabolic interference

This ensures the fluid is distributed throughout the entire volume of the trigger point, not just in a single pocket

In some embodiments, the steady state concentration of an active agent released from a controlled-release otic formulation described herein is from about 20 to about 50 times the steady state concentration of an active agent released from a formulation that is not a controlled-release otic formulation