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61 Mechanistic studies have shown significant improvements in insulin sensitivity, -cell function as well as reduction in glucagon secretion with tirzepatide 15 mg compared to semaglutide 1 mg in people with T2DM, which can explain the better efficacy of tirzepatide in improving glycemia

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However, a BPA-induced increase in cyp19a1b was not suppressed by co-application with an AR blocker 72 and BPA does not impair androgen effects in cell lines 7 , suggesting a more indirect mechanism of BPA on AR signaling