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The persistent presence of pathogens, such as viruses or bacteria, or their residual components (e.g., the spike protein of SARS-CoV-2), may function as pathogen-associated molecular patterns (PAMPs), continuously activating pattern recognition receptors (PRRs) such as Toll-like receptors (TLRs), thereby providing a potential foundational pro-inflammatory signal (122)

Identity: Confirmed through MS and peptide mapping to validate the amino acid sequence

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