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Additionally, metformin inhibits mitochondrial respiratory chain complex I, which lowers proton leak and ROS generation in hepatocyte mitochondria, thereby reducing hepatocyte apoptosis to treat DILI (99)

In this experiment, calibrated Von Frey filaments were employed to evaluate joint pain sensitivity as previously described 38,39 , the results showed that metformin treatment increased the paw withdrawal thresholds compared with those in MIA-induced OA model group (Fig

Neonatal estrogen exposure induces lobe-specific alterations in adult rat prostate androgen receptor expression

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To maintain a balanced and efficient immune response to infections and foreign invaders, it helps regulate immune cell proliferation, differentiation, and function