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Osteocalcin and irisin occupy an intermediate category, where strong preclinical biology contrasts with heterogeneous human data

For a disease that quietly threatens the heart, thats not a side benefit

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Food and Drug Administration (FDA) has not approved it yet, and it is still in late-stage clinical trials

The Phase 3 TRIUMPH-4 trial (NCT05869903) enrolled adults with obesity and knee osteoarthritis

Last reviewed: June 26, 2026 Last updated: June 26, 2026 Written by: Jay Hastings, CEO of PlexusDx Jay Hastings is the CEO of PlexusDx, a precision health company focused on genetic testing, blood biomarker insights, and personalized wellness recommendations