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GCL is in part regulated by GSH feedback inhibition, thus if GSH is depleted due to oxidative stress, inflammation, or exposure to xenobiotics, de novo synthesis of GSH is upregulated, as is cysteine synthesis

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This cycling allows receptors to resensitize and natural hormonal systems to normalize

These include: oral (swallowed into the stomach) intravenous (injected into the vein) subcutaneous (injected into the fatty tissue just under the layer of skin) Intramuscular injections may sometimes be used instead of intravenous injections because some drugs are irritating to veins or because a suitable vein cannot be located