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Covering weight loss medications will be a significant expenditure for payers on the pharmacy benefit but could potentially result in long-term savings. Arguments against coverage aside from the steep cost include the lack of historical data on efficacy and reports of gastrointestinal disturbances such as constipation, diarrhea, nausea, vomiting and severe abdominal pain

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The only way to know for sure which option is right for you is to work with a qualified provider who can assess your health, discuss your goals, and guide you through treatment

In STEP 1 (semaglutide 2.4 mg, 1,961 participants), most weight loss occurred by weeks 30 to 40, with the curve flattening after that

The microbiomes of individuals with obesity may result in increased energy absorption from food