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The clinical escalation protocol from the Phase 2 NEJM trial established a specific titration schedule that increases the dose every four weeks, starting low and building to a target maintenance dose

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It burns roughly three times more calories than fat, making it the first place your body trims energy use during a calorie deficit unless you signal that muscle is still needed

Time-to-event analyses revealed modest delays in diagnosis for key outcomes

Middle Phase Eating (Months 4-8) Side effects have resolved, appetite remains suppressed but manageable