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Across all trials, 41 deaths occurred in individuals receiving tirzepatide ( n = 4573) and 39 in the comparator arms ( n = 2151)

Priority Review designation is possible given the magnitude of the trial results, which could shorten this timeline to 6 months

265,266 When GLP-1 binds to its receptors in the hypothalamus, it activates specific neurons, including those that promote satiety (POMC/CART neurons) and inhibits those that induce hunger (NPY/AgRP neurons), thereby enhancing the feeling of fullness and reducing food intake

Protect from heat, moisture, and direct sunlight

Patients need to self-inject twice daily, which may prove inconvenient and hinder consistent use

Consuming protein within several hours before and after resistance exercise maximizes the anabolic stimulus