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Apoptosis induced by unrepaired DNA damage ROS can induce DNA damage, which appears to be a determinant of UV-induced apoptosis [51]

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J Biol Chem 277:3289232898 Rubi B, del Arco A, Bartley C, Satrustegui J, Maechler P (2004) The malate-aspartate NADH shuttle member Aralar1 determines glucose metabolic fate, mitochondrial activity, and insulin secretion in beta cells

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