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( B ) Relative protein levels of p-GSK-3, GSK-3, -catenin and TCF7L2 in Control and Emodin groups under different glucose conditions, detected by the western blot analysis

Use once daily or as tolerated

To verify whether GLP-1RAs@NPs-WYRGRL has the ability to target articular cartilage, GLP-1RAs@NPs and GLP-1RAs@NPs-WYRGRL were labeled with RBITC and injected into the experimental animals via the tail vein (Fig

To ask how -KG insufficiency depletes the cytosolic NADPH pool, we first confirmed that cytosolic NADPH-producing enzymes ME1 and IDH1 are essential for cell survival during energy stress, as previously reported 26,31 , because knockdown of either gene sensitized Huh7 and H1299 cells to glucose starvation (Supplementary Fig

Both routes lead to similar outcomes when followed properly

There is also a confidence loop