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The cells were treated for 48 h with DMSO or 10 M nutlin-3
While the PARS1 inhibitor halofuginone exhibited toxicity, its optimized derivative DWN12088 demonstrated improved safety and efficacy in preclinical models and is currently under clinical investigation for IPF [143]
Its levels can be depleted, and replenishing them with standard supplements is less effective if your body isn't absorbing them well
Therefore, the need for new therapies able to cure and prevent the progression of this condition is increasingly urgent
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