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The antinociceptive impact of DSIP was negated by the opioid antagonist naloxone and was not observed in morphine-tolerant mice, suggesting that DSIP acts at the supraspinal level, possibly influencing opioid receptors [11]

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Quinolinic acid, an intermediate formed from the pyrimidine nucleotide, enters the pyridine nucleotide cycle, where it undergoes the following steps: nicotinamide nicotinic acid nicotinic acid mononucleotide (NaMN) nicotinic acid adenine dinucleotide (NaAD) NAD nicotinamide mononucleotide (Zheng et al., 2004)

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