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In a small randomized pilot study, all six type 2 diabetic patients on the Zone diet complete disease remission within six months without loss of lean body mass, a key differentiator from GLP-1 drug therapy

Nebhwani monitors all patients closely and adjusts dosing to minimize discomfort

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Diabetes Obes Metab 14:514 Dormandy JA, Charbonnel B, Eckland DJ, Erdmann E, Massi-Benedetti M, Moules IK, The PROactive Investigators (2005) Secondary prevention of macrovascular events in patients with type 2 diabetes in the PROactive study (PROspective pioglitAzone clinical trial in macro vascular events): a randomised controlled trial

(ii) de novo lipogenesis from excess carbohydrates (glucose and fructose)