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Semaglutide is part of a class of medications that mimic a natural hormone (GLP-1) which helps regulate blood sugar and appetite

Medicare also doesnt cover medications for off-label use except when treating cancer

Thus, it is plausible that the hindbrain GLP-1 neurons are a part of the ascending pathway activated by intragastric glucose, with a role to limit reward responses perhaps

The peptide backbone of these compounds tends to undergo degradation in the infant gastrointestinal tract, further limiting systemic absorption if any traces enter breast milk

Some patients report a metallic taste or aversion to previously enjoyed foods

For drug discovery teams, the practical value is in triage and hypothesis generation