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While war interrupted Zuelzer's work, it did not prevent others from continuing to investigate the use of pancreatic extracts for diabetes elsewhere

Designed to inhibit DPP-4, the enzyme found to degrade GLP-1 (7-37), this drug, generically called sitagliptin, was developed at Merck by its first research team solely led by women

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While many of these benefits are weight-dependent, others appear at least partly weight-independent

5 Discussion GLP-1RAs have emerged as a paradigm-shifting class of agents, with therapeutic benefits that extend well beyond glycemic control in type 2 diabetes

GLP-1 receptor agonists reduce glucagon and glycogen secretion, inhibit appetite and slow gastric emptying [17] [18], creating a multifaceted approach to weight management that addresses both metabolic and behavioral components of obesity