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Broad activity across gastrointestinal, vascular, tendon, skin, bone, and CNS models may suggest involvement of fundamental biological processes such as endothelial function, cell migration, and cytoprotection

Evaluation of the immunomodulatory effect of melatonin on the T-cell response in peripheral blood from systemic lupus erythematosus patients

Overview on hydrogen sulfide-mediated suppression of vascular calcification and hemoglobin/heme-mediated vascular damage in atherosclerosis

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This has not been demonstrated in animal studies, but the mechanism warrants caution