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Each receptor targeted by retatrutide plays a critical role: 1- GLP-1 promotes satiety and stimulates insulin secretion, helping reduce appetite and improve blood sugar levels

doi: 10.1186/s12933-021-01366-8

Further medicinal chemistry optimization to improve structure activity relationship and potency as well as safety and toxicity, pharmacokinetic (bioavailability, half-life and biodistribution) and rodent in vivo studies will follow to determine the compounds potential to become suitable candidates for further development

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These include less painful menstruation, less menstrual blood loss and anemia, fewer pelvic infections, and fewer cancers of the ovary and the lining of the uterus