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The severity of melasma was assessed using a clinical severity score (MSS) and an image analysis system to quantify dermal and epidermal pigmentation

Researchers have noted dose-dependent variability in observed effects across different animal models, underscoring that findings from one species or injury model may not generalize to others

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As of February 18, 2026, the class has expanded with established agents like semaglutide, liraglutide, dulaglutide, and exenatide, alongside dual GLP-1/GIP agonists such as tirzepatide, which are often discussed in GLP-1 contexts due to overlapping mechanisms and indications

RegerMAHendersonSTHaleCCholertonBBakerLDWatsonGSet alEffects of beta-hydroxybutyrate on cognition in memory-impaired adults