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The plasma antioxidant capacity increased dose-dependently with the elevation of serum and cerebrospinal fluid UA concentrations and was associated with favorable clinical outcomes [105]

To further investigate NFT-dependent activation of Nrf2 and subsequent induction of GCL and glutathione synthesis, protein levels of the respective targets were investigated by Western blotting

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1 H NMR (400 MHz, DMSO-d6) = 10.49 (s, 1H), 8.67 (dd, J = 5.2, 1.8 Hz, 1H), 8.00 (td, J = 7.7, 1.9 Hz, 1H), 7.92 7.83 (m, 2H), 7.66 (d, J = 8.1 Hz, 1H), 7.51 (ddd, J = 7.3, 4.8, 1.1 Hz, 1H), 7.06 6.89 (m, 2H)

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when substance use ceases, normal signals feel weak, leading to withdrawal discomfort