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45% for SGLT2i and 57% for DPP4i), and more likely to be obese (72% vs

The most common reasons for amputation include diabetes-related circulation problems, severe injury, cancer, or serious infection

Notably, a recent meta-analysis of cohort studies revealed that dipeptidyl peptidase-4 inhibitors (DPP-4i) can significantly improve cognitive functions in patients with type-2 diabetes compared to other classes of glucose-lowering agents (i.e., sulfonylurea and metformin) [4]

The third guideline 1.C.21.c provides guidance for this

This rapid adoption through novel care delivery models underscores the urgent need for robust safety surveillance and comparative effectiveness research, including ones specifically focused on semaglutide

For practices operating at scale, the metabolic health EMR workflow includes templated diabetes review sections that prompt clinicians to document all active antidiabetic agents, confirm therapy duration, and tag insulin use as ongoing rather than situational