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In traumatic injuries (neurotrauma, neuroinfection, stroke or immune attack), irreversible proliferative astrogliosis is essential for wound closure and formation of a glial border that separates fibrotic scar tissue from the healthy neural tissue and promotes postlesional regeneration

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The p53 gene, as a typical tumor suppressor gene and a key regulator of cell metabolism, is closely related to the occurrence and development of ferroptosis (60)