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M., and Elhalim, A

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Pro-inflammatory cytokines are known to influence serotonin metabolism by promoting the functioning of the indoleamine 2,3-dioxygenase (IDO), thus diverting tryptophan metabolism towards the kynurenine pathway instead of the serotonin synthesis pathway

On the other hand, rs1893592, a protective UBASH3A variant, has been reported to reduce UBASH3A gene expression in human primary CD4+ T cells, which in contrast increased IL-2 secretion (79)

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