Common Side Effects (Both Oral and Injectable): Gastrointestinal Issues: These are the most common side effects for all GLP-1 medications: Nausea: Oral semaglutide (Rybelsus): 11-20% of patients Injectable semaglutide (Wegovy): 44% of patients Injectable tirzepatide (Zepbound): 30-37% of patients Why the difference: Lower bioavailability of oral medication means less systemic exposure, potentially resulting in fewer GI side effects
It can even be useful in conditions like high blood pressure, heart conditions, diabetes, cancers, and neurodegenerative disorders like Alzheimers
Key warnings include risk of thyroid C-cell tumors, pancreatitis, gallbladder disease, risk of acute kidney injury with severe gastrointestinal adverse reactions, and potential diabetic retinopathy complications
doi: 10.3389/fimmu.2021.678360 35 De VadderFKovatcheva-DatcharyPGoncalvesDVineraJZitounCDuchamptAet al
In rodent Achilles tendon transection models: BPC-157 administration led to: Higher tensile strength Faster load-bearing capacity Improved structural continuity These are functional endpoints meaning the tissue wasnt just healing histologically, but mechanically
An interesting information to notice is that the phenolic compound quercetin is also present in a plant Houttuynia cordata Thunb., along with several other antioxidant phytochemicals (Kumar et al
